Publication: Spotty calcium deposits within acute coronary syndrome (ACS)-causing culprit lesions impact inflammatory vessel-wall interactions and are associated with higher cardiovascular event rates at one year follow-up: Results from the prospective translational OPTICO-ACS study program
Spotty calcium deposits within acute coronary syndrome (ACS)-causing culprit lesions impact inflammatory vessel-wall interactions and are associated with higher cardiovascular event rates at one year follow-up: Results from the prospective translational OPTICO-ACS study program
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Nelles, G., Abdelwahed, Y. S., Alyaqoob, A., Seppelt, C., Stähli, B. E., Meteva, D., Kränkel, N., Haghikia, A., Skurk, C., Dreger, H., Knebel, F., Trippel, T. D., Krisper, M., Sieronski, L., Gerhardt, T., Zanders, L., Klotsche, J., Landmesser, U., Joner, M., & Leistner, D. M. (2023). Spotty calcium deposits within acute coronary syndrome (ACS)-causing culprit lesions impact inflammatory vessel-wall interactions and are associated with higher cardiovascular event rates at one year follow-up: Results from the prospective translational OPTICO-ACS study program. Atherosclerosis, 385, 117284. https://doi.org/10.1016/j.atherosclerosis.2023.117284
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BACKGROUND AND AIMS
Spotty calcium deposits (SCD) represent a vulnerable plaque feature which seems to result - as based on recent invitro studies - from inflammatory vessel-wall interactions. SCD can be reliably assessed by optical coherence tomography (OCT). Their prognostic impact is yet unknown. Therefore, the aims of this translational study were to comprehensively characterize different plaque calcification patterns, to analyze the associated inflammatory mechanisms in the microenvironment of acute coronary syndrome (ACS)-causi
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- Nelles, Gregor
- Abdelwahed, Youssef S
- Alyaqoob, Aseel
- Seppelt, Claudio
- Stähli, Barbara E
- Meteva, Denitsa
- Kränkel, Nicolle
- Haghikia, Arash
- Skurk, Carsten
- Dreger, Henryk
- Knebel, Fabian
- Trippel, Tobias D
- Krisper, Maximilian
- Sieronski, Lara
- Gerhardt, Teresa
- Zanders, Lukas
- Klotsche, Jens
- Landmesser, Ulf
- Joner, Michael
- Leistner, David M
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Nelles, G., Abdelwahed, Y. S., Alyaqoob, A., Seppelt, C., Stähli, B. E., Meteva, D., Kränkel, N., Haghikia, A., Skurk, C., Dreger, H., Knebel, F., Trippel, T. D., Krisper, M., Sieronski, L., Gerhardt, T., Zanders, L., Klotsche, J., Landmesser, U., Joner, M., & Leistner, D. M. (2023). Spotty calcium deposits within acute coronary syndrome (ACS)-causing culprit lesions impact inflammatory vessel-wall interactions and are associated with higher cardiovascular event rates at one year follow-up: Results from the prospective translational OPTICO-ACS study program. Atherosclerosis, 385, 117284. https://doi.org/10.1016/j.atherosclerosis.2023.117284
