Publication: The ALPK1/TIFA/NF-κB axis links a bacterial carcinogen to R-loop-induced replication stress
The ALPK1/TIFA/NF-κB axis links a bacterial carcinogen to R-loop-induced replication stress
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Bauer, M., Nascakova, Z., Mihai, A.-I., Cheng, P. F., Levesque, M. P., Lampart, S., Hurwitz, R., Pfannkuch, L., Dobrovolna, J., Jacobs, M., Bartfeld, S., Dohlman, A., Shen, X., Gall, A. A., Salama, N. R., Töpfer, A., Weber, A., Meyer, T. F., Janscak, P., & Müller, A. (2020). The ALPK1/TIFA/NF-κB axis links a bacterial carcinogen to R-loop-induced replication stress. Nature Communications, 11(1), 5117. https://doi.org/10.1038/s41467-020-18857-z
Abstract
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Abstract
Exposure of gastric epithelial cells to the bacterial carcinogen Helicobacter pylori causes DNA double strand breaks. Here, we show that H. pylori-induced DNA damage occurs co-transcriptionally in S-phase cells that activate NF-κB signaling upon innate immune recognition of the lipopolysaccharide biosynthetic intermediate β-ADP-heptose by the ALPK1/TIFA signaling pathway. DNA damage depends on the bi-functional RfaE enzyme and the Cag pathogenicity island of H. pylori, is accompanied by replication fork stalling and can be observed al
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Creators (Authors)
- Bauer, Michael
- Nascakova, Zuzana
- Mihai, Anca-Irina
- Levesque, Mitchell P
- Lampart, Simon
- Hurwitz, Robert
- Pfannkuch, Lennart
- Dobrovolna, Jana
- Jacobs, Melanie
- Bartfeld, Sina
- Dohlman, Anders
- Shen, Xiling
- Gall, Alevtina A
- Salama, Nina R
- Töpfer, Antonia
- Weber, Achim
- Meyer, Thomas F
- Janscak, Pavel
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Bauer, M., Nascakova, Z., Mihai, A.-I., Cheng, P. F., Levesque, M. P., Lampart, S., Hurwitz, R., Pfannkuch, L., Dobrovolna, J., Jacobs, M., Bartfeld, S., Dohlman, A., Shen, X., Gall, A. A., Salama, N. R., Töpfer, A., Weber, A., Meyer, T. F., Janscak, P., & Müller, A. (2020). The ALPK1/TIFA/NF-κB axis links a bacterial carcinogen to R-loop-induced replication stress. Nature Communications, 11(1), 5117. https://doi.org/10.1038/s41467-020-18857-z
