Publication: Interferon restores replication fork stability and cell viability in BRCA-defective cells via ISG15
Interferon restores replication fork stability and cell viability in BRCA-defective cells via ISG15
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Moro, R. N., Biswas, U., Kharat, S. S., Duzanic, F. D., Das, P., Stavrou, M., Raso, M. C., Freire, R., Chaudhuri, A. R., Sharan, S. K., & Penengo, L. (2023). Interferon restores replication fork stability and cell viability in BRCA-defective cells via ISG15. Nature Communications, 14(1), 6140. https://doi.org/10.1038/s41467-023-41801-w
Abstract
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Abstract
DNA replication and repair defects or genotoxic treatments trigger interferon (IFN)-mediated inflammatory responses. However, whether and how IFN signaling in turn impacts the DNA replication process has remained elusive. Here we show that basal levels of the IFN-stimulated gene 15, ISG15, and its conjugation (ISGylation) are essential to protect nascent DNA from degradation. Moreover, IFNβ treatment restores replication fork stability in BRCA1/2-deficient cells, which strictly depends on topoisomerase-1, and rescues lethality of BRCA
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- Moro, Ramona N
- Biswas, Uddipta
- Kharat, Suhas S
- Duzanic, Filip D
- Das, Prosun
- Stavrou, Maria
- Raso, Maria C
- Freire, Raimundo
- Chaudhuri, Arnab Ray
- Sharan, Shyam K
- Penengo, Lorenza
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Moro, R. N., Biswas, U., Kharat, S. S., Duzanic, F. D., Das, P., Stavrou, M., Raso, M. C., Freire, R., Chaudhuri, A. R., Sharan, S. K., & Penengo, L. (2023). Interferon restores replication fork stability and cell viability in BRCA-defective cells via ISG15. Nature Communications, 14(1), 6140. https://doi.org/10.1038/s41467-023-41801-w
