Publication: Interferon-stimulated gene 15 accelerates replication fork progression inducing chromosomal breakage
Interferon-stimulated gene 15 accelerates replication fork progression inducing chromosomal breakage
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Raso, M. C., Djoric, N., Walser, F., Hess, S., Schmid, F. M., Burger, S., Knobeloch, K.-P., & Penengo, L. (2020). Interferon-stimulated gene 15 accelerates replication fork progression inducing chromosomal breakage. Journal of Cell Biology, 219(8), 1–21. https://doi.org/10.1083/jcb.202002175
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DNA replication is highly regulated by the ubiquitin system, which plays key roles upon stress. The ubiquitin-like modifier ISG15 (interferon-stimulated gene 15) is induced by interferons, bacterial and viral infection, and DNA damage, but it is also constitutively expressed in many types of cancer, although its role in tumorigenesis is still largely elusive. Here, we show that ISG15 localizes at the replication forks, in complex with PCNA and the nascent DNA, where it regulates DNA synthesis. Indeed, high levels of ISG15, intrinsic o
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- Raso, Maria Chiara
- Djoric, Nikola
- Walser, Franziska
- Hess, Sandra
- Schmid, Fabian Marc
- Burger, Sibylle
- Knobeloch, Klaus-Peter
- Penengo, Lorenza
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Raso, M. C., Djoric, N., Walser, F., Hess, S., Schmid, F. M., Burger, S., Knobeloch, K.-P., & Penengo, L. (2020). Interferon-stimulated gene 15 accelerates replication fork progression inducing chromosomal breakage. Journal of Cell Biology, 219(8), 1–21. https://doi.org/10.1083/jcb.202002175
