Publication: Rapid droplet-based mixing for single-molecule spectroscopy
Rapid droplet-based mixing for single-molecule spectroscopy
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Yang, T., Buholzer, K. J., Sottini, A., Cao, X., deMello, A., Nettels, D., & Schuler, B. (2023). Rapid droplet-based mixing for single-molecule spectroscopy. Nature Methods, 20(10), 1479–1482. https://doi.org/10.1038/s41592-023-01995-9
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Probing non-equilibrium dynamics with single-molecule spectroscopy is important for dissecting biomolecular mechanisms. However, existing microfluidic rapid-mixing systems for this purpose are incompatible with surface-adhesive biomolecules, exhibit undesirable flow dispersion and are often demanding to fabricate. Here we introduce droplet-based microfluidic mixing for single-molecule spectroscopy to overcome these limitations in a wide range of applications. We demonstrate its robust functionality with binding kinetics of even very s
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- Yang, Tianjin
- Buholzer, Karin J
- Sottini, Andrea
- Cao, Xiaobao
- deMello, Andrew
- Nettels, Daniel
- Schuler, Benjamin
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Yang, T., Buholzer, K. J., Sottini, A., Cao, X., deMello, A., Nettels, D., & Schuler, B. (2023). Rapid droplet-based mixing for single-molecule spectroscopy. Nature Methods, 20(10), 1479–1482. https://doi.org/10.1038/s41592-023-01995-9
