Publication: Structure-function relationships of HDL in diabetes and coronary heart disease
Structure-function relationships of HDL in diabetes and coronary heart disease
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Cardner, M., Yalcinkaya, M., Goetze, S., Luca, E., Balaz, M., Hunjadi, M., Hartung, J., Shemet, A., Kränkel, N., Radosavljevic, S., Keel, M., Othman, A., Karsai, G., Hornemann, T., Claassen, M., Liebisch, G., Carreira, E., Ritsch, A., Landmesser, U., … von Eckardstein, A. (2020). Structure-function relationships of HDL in diabetes and coronary heart disease. Journal of Clinical Investigation Insight, 5(1), 131491. https://doi.org/10.1172/jci.insight.131491
Abstract
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Abstract
High-density lipoproteins (HDL) contain hundreds of lipid species and proteins and exert many potentially vasoprotective and antidiabetogenic activities on cells. To resolve structure-function-disease relationships of HDL, we characterized HDL of 51 healthy subjects and 98 patients with diabetes (T2DM), coronary heart disease (CHD), or both for protein and lipid composition, as well as functionality in 5 cell types. The integration of 40 clinical characteristics, 34 nuclear magnetic resonance (NMR) features, 182 proteins, 227 lipid sp
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Creators (Authors)
- Cardner, Mathias
- Yalcinkaya, Mustafa
- Goetze, Sandra
- Luca, Edlira
- Balaz, Miroslav
- Hunjadi, Monika
- Hartung, Johannes
- Shemet, Andrej
- Kränkel, Nicolle
- Radosavljevic, Silvija
- Keel, Michaela
- Othman, Alaa
- Karsai, Gergely
- Hornemann, Thorsten
- Claassen, Manfred
- Liebisch, Gerhard
- Carreira, Erick
- Ritsch, Andreas
- Landmesser, Ulf
- Krützfeldt, Jan
- Wolfrum, Christian
- Wollscheid, Bernd
- Beerenwinkel, Niko
- Rohrer, Lucia
- von Eckardstein, Arnold
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Cardner, M., Yalcinkaya, M., Goetze, S., Luca, E., Balaz, M., Hunjadi, M., Hartung, J., Shemet, A., Kränkel, N., Radosavljevic, S., Keel, M., Othman, A., Karsai, G., Hornemann, T., Claassen, M., Liebisch, G., Carreira, E., Ritsch, A., Landmesser, U., … von Eckardstein, A. (2020). Structure-function relationships of HDL in diabetes and coronary heart disease. Journal of Clinical Investigation Insight, 5(1), 131491. https://doi.org/10.1172/jci.insight.131491
