Prevalence of genetic susceptibility for breast and ovarian cancer in a non-cancer related study population: secondary germline findings from a Swiss single centre cohort

Kraemer, Dennis; Azzarello-Burri, Silvia; Steindl, Katharina; Boonsawat, Paranchai; Zweier, Markus; Dedes, Konstantin J; Joset, Pascal; Fink, Daniel; Rauch, Anita

doi:10.5167/uzh-179366

Citations

Citation copied

Kraemer, D., Azzarello-Burri, S., Steindl, K., Boonsawat, P., Zweier, M., Dedes, K. J., Joset, P., Fink, D., & Rauch, A. (2019). Prevalence of genetic susceptibility for breast and ovarian cancer in a non-cancer related study population: secondary germline findings from a Swiss single centre cohort. Swiss Medical Weekly, 149, w20092. https://doi.org/10.4414/smw.2019.20092

Abstract

BACKGROUND Since the advent of high-throughput sequencing technologies, organised germline screening, independent of the personal and family cancer history, has been frequently proposed. Since ethnic and geographic populations significantly differ in their mutation spectra and prevalence, one critical prerequisite would be the knowledge of the expected carrier frequencies. OBJECTIVE For the first time, in a retrospective non-cancer related cohort from a single Swiss genetic centre, we systematically assessed the prevalence of secondar