Publication: Impaired glutamate homeostasis in the nucleus accumbens in human cocaine addiction
Impaired glutamate homeostasis in the nucleus accumbens in human cocaine addiction
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Engeli, E. J. E., Zoelch, N., Hock, A., Nordt, C., Hulka, L. M., Kirschner, M., Scheidegger, M., Esposito, F., Baumgartner, M. R., Henning, A., Seifritz, E., Quednow, B. B., & Herdener, M. (2021). Impaired glutamate homeostasis in the nucleus accumbens in human cocaine addiction. Molecular Psychiatry, 26, 5277–5285. https://doi.org/10.1038/s41380-020-0828-z
Abstract
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Abstract
Cocaine addiction is characterized by overwhelming craving for the substance, which drives its escalating use despite adverse consequences. Animal models suggest a disrupted glutamate homeostasis in the nucleus accumbens to underlie addiction-like behaviour. After chronic administration of cocaine, rodents show decreased levels of accumbal glutamate, whereas drug-seeking reinstatement is associated with enhanced glutamatergic transmission. However, due to technical obstacles, the role of disturbed glutamate homeostasis for cocaine add
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- Engeli, Etna J E
- Hock, Andreas
- Hulka, Lea M
- Kirschner, Matthias
- Esposito, Fabrizio
- Henning, Anke
- Seifritz, Erich
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Engeli, E. J. E., Zoelch, N., Hock, A., Nordt, C., Hulka, L. M., Kirschner, M., Scheidegger, M., Esposito, F., Baumgartner, M. R., Henning, A., Seifritz, E., Quednow, B. B., & Herdener, M. (2021). Impaired glutamate homeostasis in the nucleus accumbens in human cocaine addiction. Molecular Psychiatry, 26, 5277–5285. https://doi.org/10.1038/s41380-020-0828-z
