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Ectopic myoglobin expression is associated with a favourable outcome in head and neck squamous cell carcinoma patients


Meller, Sebastian; Van Ellen, Anne; Gevensleben, Heidrun; Bicker, Anne; Hankeln, Thomas; Gorr, Thomas A; Sailer, Verena; Dröge, Freya; Schröck, Friederike; Bootz, Friedrich; Schröck, Andreas; Perner, Sven; Dietrich, Dimo; Kristiansen, Glen (2016). Ectopic myoglobin expression is associated with a favourable outcome in head and neck squamous cell carcinoma patients. Anticancer Research, 36(12):6235-6241.

Abstract

BACKGROUND/AIM: Ectopic myoglobin (MB) expression, mediated by alternative and hypoxia-inducible transcription, has recently been demonstrated in several epithelial tumours. This study aimed to examine the expression of MB in hormone-independent head and neck squamous cell carcinomas (HNSCCs).
PATIENTS AND METHODS: Using imunohistochemistry, ectopic MB expression was analyzed on tissue microarrays (TMAs) of 524 patients with localized and locally advanced primary and recurrent HNSCC who had undergone surgical treatment with curative intent. Associations of MB expression with survival and clinicopathological parameters were analyzed.
RESULTS: MB expression was found in 45.8% of HNSCC patients being significantly lower in normal adjacent tissue (NAT) compared to primary and recurrent tumours (p<0.001) and significantly associated with a favourable overall survival (OS) in HNSCC [p=0.037, hazard ratio (HR)=0.72, 95% confidence interval (CI)=0.53-0.98]. Furthermore, MB expression negatively correlated with human papillomavirus (HPV) status (p=0.013).
CONCLUSION: MB is differentially expressed in HNSCC and correlates with a better OS.

Abstract

BACKGROUND/AIM: Ectopic myoglobin (MB) expression, mediated by alternative and hypoxia-inducible transcription, has recently been demonstrated in several epithelial tumours. This study aimed to examine the expression of MB in hormone-independent head and neck squamous cell carcinomas (HNSCCs).
PATIENTS AND METHODS: Using imunohistochemistry, ectopic MB expression was analyzed on tissue microarrays (TMAs) of 524 patients with localized and locally advanced primary and recurrent HNSCC who had undergone surgical treatment with curative intent. Associations of MB expression with survival and clinicopathological parameters were analyzed.
RESULTS: MB expression was found in 45.8% of HNSCC patients being significantly lower in normal adjacent tissue (NAT) compared to primary and recurrent tumours (p<0.001) and significantly associated with a favourable overall survival (OS) in HNSCC [p=0.037, hazard ratio (HR)=0.72, 95% confidence interval (CI)=0.53-0.98]. Furthermore, MB expression negatively correlated with human papillomavirus (HPV) status (p=0.013).
CONCLUSION: MB is differentially expressed in HNSCC and correlates with a better OS.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Physiology
Dewey Decimal Classification:570 Life sciences; biology
Uncontrolled Keywords:HPV, Myoglobin, head and neck squamous cell carcinoma, prognosis
Language:English
Date:December 2016
Deposited On:02 Feb 2017 12:49
Last Modified:02 Feb 2018 11:58
Publisher:International Institute of Anticancer Research
ISSN:0250-7005
OA Status:Closed
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.21873/anticanres.11217
PubMed ID:27919941

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