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Neuropharmacological modulation of the aberrant bodily self through psychedelics


Ho, Jasmine T; Preller, Katrin H; Lenggenhager, Bigna (2020). Neuropharmacological modulation of the aberrant bodily self through psychedelics. Neuroscience and Biobehavioral Reviews, 108:526-541.

Abstract

As a continual source of sensory input and fundamental component of self-referential processing, the body holds an integral modulatory role in cognition. In a healthy state, predictive coding of multisensory integration promotes the construction of a coherent self. However, several psychiatric disorders comprise aberrant perceptions of the bodily self that are purported to involve discrepancies in the integration and updating of multisensory systems. Changes in functional connectivity of somatomotor and high-level association networks in these disorders could be successfully remediated through 5-HT2A receptor agonism via psychedelics. Reported alterations of bodily self-awareness during psychedelic experiences allude to a potentially central role of the bodily self. In this article, we bridge the domains of (aberrant) bodily self-awareness and psychedelics by discussing the predictive coding mechanisms underlying the bodily self and psychedelics. Furthermore, we propose that psychedelically-induced desynchronization of predictive coding might involve modulation of somatomotor, sensorimotor, and high-level association networks that could remediate aberrant perceptions of the bodily self.

Abstract

As a continual source of sensory input and fundamental component of self-referential processing, the body holds an integral modulatory role in cognition. In a healthy state, predictive coding of multisensory integration promotes the construction of a coherent self. However, several psychiatric disorders comprise aberrant perceptions of the bodily self that are purported to involve discrepancies in the integration and updating of multisensory systems. Changes in functional connectivity of somatomotor and high-level association networks in these disorders could be successfully remediated through 5-HT2A receptor agonism via psychedelics. Reported alterations of bodily self-awareness during psychedelic experiences allude to a potentially central role of the bodily self. In this article, we bridge the domains of (aberrant) bodily self-awareness and psychedelics by discussing the predictive coding mechanisms underlying the bodily self and psychedelics. Furthermore, we propose that psychedelically-induced desynchronization of predictive coding might involve modulation of somatomotor, sensorimotor, and high-level association networks that could remediate aberrant perceptions of the bodily self.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Psychiatry, Psychotherapy, and Psychosomatics
06 Faculty of Arts > Institute of Psychology
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:Cognitive Neuroscience, Behavioral Neuroscience, Neuropsychology and Physiological Psychology
Language:English
Date:1 January 2020
Deposited On:14 Jan 2020 11:55
Last Modified:20 Jan 2020 13:39
Publisher:Elsevier
ISSN:0149-7634
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.neubiorev.2019.12.006
PubMed ID:31816361
Project Information:
  • : FunderSNSF
  • : Grant IDPP00P1_170511
  • : Project TitlePlasticity of the bodily self in a life span approach

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