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Lung donation after circulatory death


Ceulemans, Laurens J; Inci, Ilhan; Van Raemdonck, Dirk (2019). Lung donation after circulatory death. Current Opinion in Organ Transplantation, 24(3):288-296.

Abstract

PURPOSE OF REVIEW

The current review presents a concise update on published literature on donation after circulatory death (DCD) and lung transplantation (LTx). Worldwide an increasing need for lungs is evident, however the utilization rate of DCD lung donors is still considerably low. In this summary article, we reviewed both the experimental background and international clinical experience.

RECENT FINDINGS

Our analysis confirmed satisfactory results for LTx from DCD donors, which equals the results from donation after brain death. Although most studies reported on short-term results, some confirmed these results on the long-term and development of chronic lung allograft dysfunction. Our review summarizes the different DCD categories and underlines the potential of the DCD V category. We analyze the barriers to implement a DCD program, discuss the more recent advances like ex-vivo lung perfusion and describe the future challenges.

SUMMARY

Based on the current short-term and long-term clinical results, we believe that barriers for DCD utilization should be overcome, resulting in a safe implementation of more DCD LTx programs worldwide. VIDEO ABSTRACT.

Abstract

PURPOSE OF REVIEW

The current review presents a concise update on published literature on donation after circulatory death (DCD) and lung transplantation (LTx). Worldwide an increasing need for lungs is evident, however the utilization rate of DCD lung donors is still considerably low. In this summary article, we reviewed both the experimental background and international clinical experience.

RECENT FINDINGS

Our analysis confirmed satisfactory results for LTx from DCD donors, which equals the results from donation after brain death. Although most studies reported on short-term results, some confirmed these results on the long-term and development of chronic lung allograft dysfunction. Our review summarizes the different DCD categories and underlines the potential of the DCD V category. We analyze the barriers to implement a DCD program, discuss the more recent advances like ex-vivo lung perfusion and describe the future challenges.

SUMMARY

Based on the current short-term and long-term clinical results, we believe that barriers for DCD utilization should be overcome, resulting in a safe implementation of more DCD LTx programs worldwide. VIDEO ABSTRACT.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Thoracic Surgery
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:1 June 2019
Deposited On:10 Feb 2020 15:50
Last Modified:10 Feb 2020 15:50
Publisher:Lippincott Williams & Wilkins
ISSN:1087-2418
OA Status:Closed
Publisher DOI:https://doi.org/10.1097/MOT.0000000000000627
PubMed ID:31090638

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Content: Published Version
Language: English
Filetype: PDF - Registered users only until 1 June 2020
Size: 369kB
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Embargo till: 2020-06-01