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1,3-Dioxolane – Determination of 1,3-dioxolane in workplace air using gas chromatography (GC-FID)


Klimach, A.L.; Hebisch, R; Brock, T H; Schmitt, R; Hartwig, A; MAK Commission; Arand, Michael (2023). 1,3-Dioxolane – Determination of 1,3-dioxolane in workplace air using gas chromatography (GC-FID). The MAK Collection for Occupational Health and Safety, 8(1):Doc028.

Abstract

This analytical method is a validated measurement procedure for the determination of 1,3-dioxolane [646-06-0] in workplace air in a concentration range of one tenth up to twice the currently valid Occupational Exposure Limit Value (OELV) in Germany of 150 mg/m3. For sampling, a defined volume of air is drawn through a sorbent tube (for thermal desorption) filled with Chromosorb 106. The flow rate is set to 5 ml/min and sampling is performed over 2 hours (which corresponds to a sampling volume of 600 ml). The samples to which cyclooctane is added as internal standard are thermally desorbed. The quantitative determination is based on a calibration function, whereby the 1,3-dioxolane concentration of the calibration standard is plotted against the intensities, calculated over the internal cyclooctane standard. The limit of quantification is 12.9 mg/m3 based on an air sample volume of 600 ml. The mean recovery is 97% and the expanded uncertainty for the validation range of 16.3 to 293 mg/m3 is 11.5 to 12.1%.

Abstract

This analytical method is a validated measurement procedure for the determination of 1,3-dioxolane [646-06-0] in workplace air in a concentration range of one tenth up to twice the currently valid Occupational Exposure Limit Value (OELV) in Germany of 150 mg/m3. For sampling, a defined volume of air is drawn through a sorbent tube (for thermal desorption) filled with Chromosorb 106. The flow rate is set to 5 ml/min and sampling is performed over 2 hours (which corresponds to a sampling volume of 600 ml). The samples to which cyclooctane is added as internal standard are thermally desorbed. The quantitative determination is based on a calibration function, whereby the 1,3-dioxolane concentration of the calibration standard is plotted against the intensities, calculated over the internal cyclooctane standard. The limit of quantification is 12.9 mg/m3 based on an air sample volume of 600 ml. The mean recovery is 97% and the expanded uncertainty for the validation range of 16.3 to 293 mg/m3 is 11.5 to 12.1%.

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Additional indexing

Item Type:Journal Article, not_refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:610 Medicine & health
570 Life sciences; biology
Language:English
Date:2023
Deposited On:12 Feb 2024 14:53
Last Modified:12 Feb 2024 14:54
Publisher:German Medical Science
ISSN:2509-2383
OA Status:Gold
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.34865/am64606e8_1or
  • Content: Published Version
  • Language: English
  • Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)