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Nievergelt, Philipp; Berliat, Florian; McAuley, Katherine E; Dorgan, Colin R; van Well, Renate Maria; Thorn, Andrea; Spingler, Bernhard (2024). RNA oligomers at atomic resolution containing 1‐methylpseudouridine, an essential building block of mRNA vaccines. ChemMedChem, 19(7):e202300600.
All widely used mRNA vaccines against COVID‐19 contain in their sequence 1‐methylpseudouridine (m1Ψ) instead of uridine. In this publication, we report two high resolution crystal structures (at up to 1.01 and 1.32 Å, respectively) of one such double‐stranded 12‐mer RNA sequence crystallized in two crystal forms. The structures are compared with similar structures which do not contain this modification. Additionally, the X‐ray structure of 1‐methyl‐pseudouridine itself was determined.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 07 Faculty of Science > Department of Chemistry |
| Dewey Decimal Classification: | 540 Chemistry |
| Scopus Subject Areas: | Life Sciences > Biochemistry
Life Sciences > Molecular Medicine Life Sciences > Pharmacology Life Sciences > Drug Discovery Life Sciences > General Pharmacology, Toxicology and Pharmaceutics Physical Sciences > Organic Chemistry |
| Uncontrolled Keywords: | Organic Chemistry, General Pharmacology, Toxicology and Pharmaceutics, Molecular Medicine, Drug Discovery, Biochemistry, Pharmacology |
| Language: | English |
| Date: | 2 April 2024 |
| Deposited On: | 26 Apr 2024 09:30 |
| Last Modified: | 31 Dec 2024 02:37 |
| Publisher: | Wiley-Blackwell Publishing, Inc. |
| ISSN: | 1860-7179 |
| OA Status: | Hybrid |
| Publisher DOI: | https://doi.org/10.1002/cmdc.202300600 |
| PubMed ID: | 38235959 |
| Project Information: |
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Nievergelt, Philipp