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Impaired semantic processing during sentence reading in children with dyslexia: combined fMRI and ERP evidence

Schulz, E; Maurer, Urs; van der Mark, S; Bucher, K; Brem, S; Martin, E; Brandeis, D (2008). Impaired semantic processing during sentence reading in children with dyslexia: combined fMRI and ERP evidence. NeuroImage, 41(1):153-168.

Abstract

Developmental dyslexia is a specific disorder of reading acquisition characterized by a phonological core deficit. Sentence reading is also impaired in dyslexic readers, but whether semantic processing deficits contribute is unclear. Combining spatially and temporally sensitive neuroimaging techniques to focus on semantic processing can provide a more comprehensive characterization of sentence reading in dyslexia. We recorded brain activity from 52 children (16 with dyslexia, 31 controls) with functional magnetic resonance imaging (fMRI) and event-related potentials (ERP) in two separate counterbalanced sessions. The children silently read and occasionally judged simple sentences with semantically congruous or incongruous endings. fMRI and ERP activation during sentence reading and semantic processing was analyzed across all children and also by comparing children with dyslexia to controls. For sentence reading, we analyzed the response to all words in a sentence; for semantic processing, we contrasted responses to incongruous and congruous endings. Sentence reading was characterized by activation in a left-lateralized language network. Semantic processing was characterized by activation in left-hemispheric regions of the inferior frontal and superior temporal cortex and by an electrophysiological N400 effect after 240 ms with consistent left anterior source localization. Children with dyslexia showed decreased activation for sentence reading in inferior parietal and frontal regions, and for semantic processing in inferior parietal regions, and during the N400 effect. Together, this suggests that semantic impairment during sentence reading reduces dyslexic children's response in left anterior brain regions underlying the more phasic N400 effect and subsequently modulates the more sustained BOLD response in left inferior parietal regions.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
04 Faculty of Medicine > Psychiatric University Hospital Zurich > Department of Child and Adolescent Psychiatry
04 Faculty of Medicine > Zurich Center for Integrative Human Physiology (ZIHP)
06 Faculty of Arts > Institute of Psychology
Dewey Decimal Classification:570 Life sciences; biology
150 Psychology
610 Medicine & health
Scopus Subject Areas:Life Sciences > Neurology
Life Sciences > Cognitive Neuroscience
Language:English
Date:15 May 2008
Deposited On:07 Nov 2008 15:30
Last Modified:01 Nov 2024 02:39
Publisher:Elsevier
ISSN:1053-8119
OA Status:Green
Publisher DOI:https://doi.org/10.1016/j.neuroimage.2008.02.012
PubMed ID:18378166
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